ATP-dependent complexes slide or evict nucleosomes to control access to DNA.
Complexes such as SWI/SNF use ATP to slide, eject or restructure nucleosomes, exposing promoters. Mutations in subunits occur in about 20 percent of cancers.
Remodellers work with histone modifiers and transcription factors.
ATP-dependent complexes slide or evict nucleosomes to control access to DNA.
Chromatin Remodelling is one of the 52 topics in Molecular Biology. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Mediator Complex, Promoter, DNA Packaging.
Nucleosome remodelling is needed to open the promoter of the interferon-beta gene on viral infection.
Work through the Beginner topics in Molecular Biology first, such as Central Dogma, DNA Replication, Base Pairing, then return to Chromatin Remodelling. Advanced topics assume the Intermediate vocabulary.
The closest topics to Chromatin Remodelling are Mediator Complex, Promoter, DNA Packaging, Enhancers and Silencers. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Chromatin Remodelling. To practise the whole of Molecular Biology, use the Molecular Biology quiz.
Chromatin Remodelling: ATP-dependent complexes slide or evict nucleosomes to control access to DNA. Mediator Complex: A large multi-protein assembly that links enhancer-bound transcription factors to RNA polymerase II. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Mediator Complex and explain the difference aloud. Finally, take the Molecular Biology quiz and come back to this page for any question you miss.
A large multi-protein assembly that links enhancer-bound transcription factors to RNA polymerase II.
🧫 Molecular BiologyA DNA sequence where RNA polymerase and transcription factors bind to start transcription of a gene.
🧫 Molecular BiologyDNA wraps around histone proteins to form nucleosomes that coil into compact chromatin.
🧫 Molecular BiologyDistant regulatory DNA elements that increase or decrease transcription via looping to the promoter.
🧫 Molecular Biology