The end product of a pathway inhibits an early enzyme, preventing overproduction.
The final product binds to an allosteric site on the first committed enzyme and slows the pathway, saving energy and materials. When the product level drops, inhibition lifts.
It is a form of negative feedback at the molecular level.
The end product of a pathway inhibits an early enzyme, preventing overproduction.
Feedback Inhibition is one of the 51 topics in Biomolecules & Biochemistry. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Noncompetitive Inhibition, Competitive Inhibition, Factors Affecting Enzymes.
CTP inhibits aspartate transcarbamoylase in pyrimidine synthesis.
Work through the Beginner topics in Biomolecules & Biochemistry first, such as Water Properties, Carbon Chemistry, Carbohydrates, then return to Feedback Inhibition. Advanced topics assume the Intermediate vocabulary.
The closest topics to Feedback Inhibition are Noncompetitive Inhibition, Competitive Inhibition, Factors Affecting Enzymes, Active Site. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Feedback Inhibition. To practise the whole of Biomolecules & Biochemistry, use the Biomolecules & Biochemistry quiz.
Feedback Inhibition: The end product of a pathway inhibits an early enzyme, preventing overproduction. Noncompetitive Inhibition: An inhibitor binds elsewhere on the enzyme, lowering Vmax without changing Km. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Noncompetitive Inhibition and explain the difference aloud. Finally, take the Biomolecules & Biochemistry quiz and come back to this page for any question you miss.
An inhibitor binds elsewhere on the enzyme, lowering Vmax without changing Km.
⚗️ Biomolecules & BiochemistryAn inhibitor resembling the substrate binds the active site and can be overcome by more substrate.
⚗️ Biomolecules & BiochemistryTemperature, pH, substrate and enzyme concentration, and inhibitors all alter the rate of enzyme-catalysed reactions.
⚗️ Biomolecules & BiochemistryThe specific pocket on an enzyme where the substrate binds and the reaction takes place.
⚗️ Biomolecules & Biochemistry