Summary
A set of equations describing how sodium and potassium conductances produce the action potential.
In depth
Based on giant squid axon experiments (1952, Nobel 1963). Membrane current is the sum of capacitive, Na+, K+ and leak currents with gating variables m, h and n. It predicted threshold, spike shape and refractoriness.
The model reproduced the action potential using measured conductances. It laid the basis of computational neuroscience.
Remember: voltage clamp was a key technique in its development.
Frequently asked questions
What is Hodgkin-Huxley Model?
A set of equations describing how sodium and potassium conductances produce the action potential.
Which area of biology covers Hodgkin-Huxley Model, and how advanced is it?
Hodgkin-Huxley Model is one of the 54 topics in Neuroscience. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Action Potential, Voltage-Gated Ion Channels, Depolarisation and Repolarisation.
Can you give an example of Hodgkin-Huxley Model?
Modern neuron simulators extend the model.
What should I learn before Hodgkin-Huxley Model?
Work through the Beginner topics in Neuroscience first, such as Nervous System, Neuron, Central and Peripheral Nervous Systems, then return to Hodgkin-Huxley Model. Advanced topics assume the Intermediate vocabulary.
What topics are related to Hodgkin-Huxley Model?
The closest topics to Hodgkin-Huxley Model are Action Potential, Voltage-Gated Ion Channels, Depolarisation and Repolarisation, Resting Membrane Potential. Comparing them side by side is a good way to see how the ideas connect.
How can I check that I understand Hodgkin-Huxley Model?
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Hodgkin-Huxley Model. To practise the whole of Neuroscience, use the Neuroscience quiz.
How is Hodgkin-Huxley Model different from Action Potential?
Hodgkin-Huxley Model: A set of equations describing how sodium and potassium conductances produce the action potential. Action Potential: A rapid, all-or-none reversal of membrane potential that travels along an axon. Read both side by side and note what each one explains.
How should I study Hodgkin-Huxley Model step by step?
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Action Potential and explain the difference aloud. Finally, take the Neuroscience quiz and come back to this page for any question you miss.