Proposes that most molecular variation results from drift of selectively neutral mutations rather than selection.
Motoo Kimura argued that most fixed molecular differences are neutral, with drift determining their fate. It does not deny selection on phenotype but changed how molecular evolution is viewed and gave a null model.
Neutral changes accumulate at a rate equal to the mutation rate, which underlies the molecular clock.
Proposes that most molecular variation results from drift of selectively neutral mutations rather than selection.
Neutral Theory is one of the 53 topics in Evolution. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Molecular Clock, Evolution, Evolution of Sex.
Synonymous sites evolve faster than nonsynonymous sites since they are under less constraint.
Work through the Beginner topics in Evolution first, such as Evolution, Natural Selection, Charles Darwin, then return to Neutral Theory. Advanced topics assume the Intermediate vocabulary.
The closest topics to Neutral Theory are Molecular Clock, Evolution, Evolution of Sex, Punctuated Equilibrium. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Neutral Theory. To practise the whole of Evolution, use the Evolution quiz.
Neutral Theory: Proposes that most molecular variation results from drift of selectively neutral mutations rather than selection. Molecular Clock: Uses the steady rate of neutral mutations to estimate when lineages diverged. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Molecular Clock and explain the difference aloud. Finally, take the Evolution quiz and come back to this page for any question you miss.
Uses the steady rate of neutral mutations to estimate when lineages diverged.
🦎 EvolutionChange in the inherited characteristics of populations over successive generations.
🦎 EvolutionHypotheses explain why sexual reproduction persists despite its costs, including the Red Queen and mutation clearance.
🦎 EvolutionSuggests species remain stable for long periods interrupted by short bursts of rapid change.
🦎 Evolution