Chemical changes such as phosphorylation, glycosylation and ubiquitination that regulate protein activity and fate.
Phosphorylation by kinases switches proteins on or off, glycosylation helps folding and targeting, acetylation and methylation regulate histones, and ubiquitination marks proteins for degradation. Proteolytic cleavage activates others, such as insulin from proinsulin.
A single protein can have many modification sites forming a regulatory code.
Chemical changes such as phosphorylation, glycosylation and ubiquitination that regulate protein activity and fate.
Protein Post-Translational Modification is one of the 51 topics in Biomolecules & Biochemistry. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Proteins, Protein Folding and Chaperones, Allosteric Regulation.
P53 is stabilised by phosphorylation after DNA damage.
Work through the Beginner topics in Biomolecules & Biochemistry first, such as Water Properties, Carbon Chemistry, Carbohydrates, then return to Protein Post-Translational Modification. Advanced topics assume the Intermediate vocabulary.
The closest topics to Protein Post-Translational Modification are Proteins, Protein Folding and Chaperones, Allosteric Regulation, RNA Types. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Protein Post-Translational Modification. To practise the whole of Biomolecules & Biochemistry, use the Biomolecules & Biochemistry quiz.
Protein Post-Translational Modification: Chemical changes such as phosphorylation, glycosylation and ubiquitination that regulate protein activity and fate. Proteins: Polymers of amino acids that act as enzymes, structural parts, transporters, hormones and antibodies. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Proteins and explain the difference aloud. Finally, take the Biomolecules & Biochemistry quiz and come back to this page for any question you miss.
Polymers of amino acids that act as enzymes, structural parts, transporters, hormones and antibodies.
⚗️ Biomolecules & BiochemistryChaperone proteins such as Hsp70 help nascent polypeptides reach their native fold and prevent aggregation.
⚗️ Biomolecules & BiochemistryBinding of a molecule at a site other than the active site changes enzyme shape and activity.
⚗️ Biomolecules & BiochemistryMessenger, transfer and ribosomal RNA, each with a distinct role in protein synthesis.
⚗️ Biomolecules & Biochemistry