Summary
Cholesterol is converted stepwise by enzymes like aromatase into androgens and oestrogens.
In depth
Cholesterol to pregnenolone to progesterone, then androgens (androstenedione, testosterone) and oestrogens via aromatase. Tissues differ in enzyme sets. Aromatase inhibitors treat oestrogen-sensitive breast cancer.
Enzymes determine whether androgens or oestrogens are made. Peripheral conversion (in fat) is important in post-menopause. Inhibitors treat hormone-sensitive cancers.
Remember: all sex steroids derive from cholesterol.
Frequently asked questions
What is Sex Steroid Biosynthesis?
Cholesterol is converted stepwise by enzymes like aromatase into androgens and oestrogens.
Which area of biology covers Sex Steroid Biosynthesis, and how advanced is it?
Sex Steroid Biosynthesis is one of the 54 topics in Reproduction & Endocrinology. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Steroid and Peptide Hormone Mechanisms, Pregnancy Hormones, Reproductive Ageing.
Can you give an example of Sex Steroid Biosynthesis?
Testosterone is converted to DHT by 5-alpha reductase.
What should I learn before Sex Steroid Biosynthesis?
Work through the Beginner topics in Reproduction & Endocrinology first, such as Reproduction, Asexual Reproduction, Sexual Reproduction, then return to Sex Steroid Biosynthesis. Advanced topics assume the Intermediate vocabulary.
What topics are related to Sex Steroid Biosynthesis?
The closest topics to Sex Steroid Biosynthesis are Steroid and Peptide Hormone Mechanisms, Pregnancy Hormones, Reproductive Ageing, Lactation. Comparing them side by side is a good way to see how the ideas connect.
How can I check that I understand Sex Steroid Biosynthesis?
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Sex Steroid Biosynthesis. To practise the whole of Reproduction & Endocrinology, use the Reproduction & Endocrinology quiz.
How is Sex Steroid Biosynthesis different from Steroid and Peptide Hormone Mechanisms?
Sex Steroid Biosynthesis: Cholesterol is converted stepwise by enzymes like aromatase into androgens and oestrogens. Steroid and Peptide Hormone Mechanisms: Steroid hormones cross membranes and alter transcription; peptide hormones bind surface receptors and activate second messengers. Read both side by side and note what each one explains.
How should I study Sex Steroid Biosynthesis step by step?
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Steroid and Peptide Hormone Mechanisms and explain the difference aloud. Finally, take the Reproduction & Endocrinology quiz and come back to this page for any question you miss.