A ribonucleoprotein that guides ribosomes making secretory proteins to the endoplasmic reticulum membrane.
When a ribosome starts translating a protein with an N-terminal signal sequence, SRP binds the sequence, pauses translation and docks the complex at the SRP receptor on the ER, where the ribosome is passed to a translocon. Translation then resumes and the chain threads into the ER lumen.
The signal peptide is often cut off by signal peptidase.
A ribonucleoprotein that guides ribosomes making secretory proteins to the endoplasmic reticulum membrane.
Signal Recognition Particle is one of the 52 topics in Cell Biology. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Ribosome, Endoplasmic Reticulum, Plasma Membrane.
This is how secreted proteins like insulin and membrane proteins are directed to the right place.
Work through the Beginner topics in Cell Biology first, such as Cell Theory, Prokaryotic Cell, Eukaryotic Cell, then return to Signal Recognition Particle. Advanced topics assume the Intermediate vocabulary.
The closest topics to Signal Recognition Particle are Ribosome, Endoplasmic Reticulum, Plasma Membrane, Eukaryotic Cell. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Signal Recognition Particle. To practise the whole of Cell Biology, use the Cell Biology quiz.
Signal Recognition Particle: A ribonucleoprotein that guides ribosomes making secretory proteins to the endoplasmic reticulum membrane. Ribosome: A small particle of RNA and protein that assembles amino acids into polypeptides during translation. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Ribosome and explain the difference aloud. Finally, take the Cell Biology quiz and come back to this page for any question you miss.
A small particle of RNA and protein that assembles amino acids into polypeptides during translation.
🔬 Cell BiologyA network of membrane tubes and sacs; the rough form makes proteins and the smooth form makes lipids.
🔬 Cell BiologyThe thin, selectively permeable phospholipid boundary that separates the inside of a cell from its surroundings.
🔬 Cell BiologyA complex cell with a true nucleus and membrane-bound organelles, found in animals, plants, fungi and protists.
🔬 Cell Biology