Genome-scale models predict growth and pathway usage under constraints.
Genome-scale models such as Recon3D link thousands of reactions. Flux balance analysis optimises an objective (e.g. growth). Used for drug target identification and metabolic engineering.
Constraint-based models predict flux with minimal data. Integrating omics improves predictions. Models guide diagnosis and strain design.
Key idea: metabolism is a network, not a set of isolated pathways.
Genome-scale models predict growth and pathway usage under constraints.
Systems Biology of Metabolism is one of the 53 topics in Metabolism & Bioenergetics. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Metabolic Engineering, Metabolomics, Metabolic Flux Analysis.
Models predict gene essentiality in bacteria.
Work through the Beginner topics in Metabolism & Bioenergetics first, such as Metabolism, Anabolism and Catabolism, ATP, then return to Systems Biology of Metabolism. Advanced topics assume the Intermediate vocabulary.
The closest topics to Systems Biology of Metabolism are Metabolic Engineering, Metabolomics, Metabolic Flux Analysis, Metabolism. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Systems Biology of Metabolism. To practise the whole of Metabolism & Bioenergetics, use the Metabolism & Bioenergetics quiz.
Systems Biology of Metabolism: Genome-scale models predict growth and pathway usage under constraints. Metabolic Engineering: Rewiring pathways in microbes to produce fuels, drugs and chemicals. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Metabolic Engineering and explain the difference aloud. Finally, take the Metabolism & Bioenergetics quiz and come back to this page for any question you miss.
Rewiring pathways in microbes to produce fuels, drugs and chemicals.
⚡ Metabolism & BioenergeticsLarge-scale measurement of small metabolites to profile the physiological state of cells and tissues.
⚡ Metabolism & BioenergeticsUses isotope tracers and models to measure reaction rates through metabolic networks.
⚡ Metabolism & BioenergeticsThe sum of all chemical reactions in an organism, including anabolic building and catabolic breakdown.
⚡ Metabolism & Bioenergetics