Summary
An integrative approach modelling interactions among genes, proteins and metabolites as networks.
In depth
Combines experiments and computation to study networks of interactions. Tools: omics data, network analysis, ODE models and Boolean models. Emphasises emergent properties such as oscillations and robustness.
Integrates measurement, modelling and perturbation. Network motifs such as feedback and feed-forward loops give dynamic behaviours. Whole-cell models simulate all processes in a minimal bacterium.
Key idea: understanding parts is not enough, one must study their interactions.
Frequently asked questions
What is Systems Biology?
An integrative approach modelling interactions among genes, proteins and metabolites as networks.
Which area of biology covers Systems Biology, and how advanced is it?
Systems Biology is one of the 56 topics in Biotechnology & Genomics. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Synthetic Biology, Machine Learning in Biology, Proteomics.
Can you give an example of Systems Biology?
Modelling the cell cycle as a bistable switch.
What should I learn before Systems Biology?
Work through the Beginner topics in Biotechnology & Genomics first, such as Biotechnology, Genetic Engineering, Selective Breeding, then return to Systems Biology. Advanced topics assume the Intermediate vocabulary.
What topics are related to Systems Biology?
The closest topics to Systems Biology are Synthetic Biology, Machine Learning in Biology, Proteomics, Bioinformatics. Comparing them side by side is a good way to see how the ideas connect.
How can I check that I understand Systems Biology?
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Systems Biology. To practise the whole of Biotechnology & Genomics, use the Biotechnology & Genomics quiz.
How is Systems Biology different from Synthetic Biology?
Systems Biology: An integrative approach modelling interactions among genes, proteins and metabolites as networks. Synthetic Biology: Designing and building new biological parts, circuits and organisms with engineering principles. Read both side by side and note what each one explains.
How should I study Systems Biology step by step?
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Synthetic Biology and explain the difference aloud. Finally, take the Biotechnology & Genomics quiz and come back to this page for any question you miss.