Regulation of protein synthesis rate through initiation factors, upstream open reading frames and mRNA stability.
Regulation includes phosphorylation of eIF2 under stress (slowing global translation), regulated mRNA binding proteins, miRNAs and upstream ORFs. Iron levels control ferritin translation through an iron-response element.
Fast responses do not need new transcription.
Regulation of protein synthesis rate through initiation factors, upstream open reading frames and mRNA stability.
Translational Control is one of the 52 topics in Molecular Biology. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Ubiquitin-Proteasome System, Transcription Factors, Operon.
The integrated stress response reduces general protein synthesis but boosts ATF4.
Work through the Beginner topics in Molecular Biology first, such as Central Dogma, DNA Replication, Base Pairing, then return to Translational Control. Advanced topics assume the Intermediate vocabulary.
The closest topics to Translational Control are Ubiquitin-Proteasome System, Transcription Factors, Operon, Gene Expression. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Translational Control. To practise the whole of Molecular Biology, use the Molecular Biology quiz.
Translational Control: Regulation of protein synthesis rate through initiation factors, upstream open reading frames and mRNA stability. Ubiquitin-Proteasome System: Ubiquitin tagging marks proteins for destruction by the proteasome to control protein levels. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Ubiquitin-Proteasome System and explain the difference aloud. Finally, take the Molecular Biology quiz and come back to this page for any question you miss.
Ubiquitin tagging marks proteins for destruction by the proteasome to control protein levels.
🧫 Molecular BiologyProteins that bind specific DNA sequences to turn genes on or off.
🧫 Molecular BiologyA cluster of bacterial genes under one promoter and operator, regulated together.
🧫 Molecular BiologyThe process by which information in a gene is used to make a functional product.
🧫 Molecular Biology