Lactate from muscle is converted to glucose in the liver and returned, costing net ATP.
Lactate from muscle goes to the liver, is converted to glucose via gluconeogenesis (costing 6 ATP) and returns to muscle. It shifts the metabolic burden from muscle to liver.
It moves lactate from muscle to liver, allowing continued anaerobic glycolysis in muscle during intense exercise. The liver pays the energy cost.
Example: it helps maintain blood glucose during sprinting.
Lactate from muscle is converted to glucose in the liver and returned, costing net ATP.
Cori Cycle is one of the 53 topics in Metabolism & Bioenergetics. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Gluconeogenesis, Lactic Acid Fermentation, Glucose as Fuel.
It explains why exercise raises blood lactate and liver activity.
Work through the Beginner topics in Metabolism & Bioenergetics first, such as Metabolism, Anabolism and Catabolism, ATP, then return to Cori Cycle. Advanced topics assume the Intermediate vocabulary.
The closest topics to Cori Cycle are Gluconeogenesis, Lactic Acid Fermentation, Glucose as Fuel, Bioenergetics of Muscle. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Cori Cycle. To practise the whole of Metabolism & Bioenergetics, use the Metabolism & Bioenergetics quiz.
Cori Cycle: Lactate from muscle is converted to glucose in the liver and returned, costing net ATP. Gluconeogenesis: Synthesis of glucose from non-carbohydrate precursors such as lactate and amino acids, mainly in the liver. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Gluconeogenesis and explain the difference aloud. Finally, take the Metabolism & Bioenergetics quiz and come back to this page for any question you miss.
Synthesis of glucose from non-carbohydrate precursors such as lactate and amino acids, mainly in the liver.
⚡ Metabolism & BioenergeticsPyruvate is converted to lactate when oxygen is lacking, regenerating NAD+ for glycolysis.
⚡ Metabolism & BioenergeticsThe main sugar broken down to supply cellular energy.
⚡ Metabolism & BioenergeticsPhosphocreatine, glycolysis and oxidative metabolism supply ATP at different timescales of exercise.
⚡ Metabolism & Bioenergetics