Heritable changes in gene activity, through DNA methylation and histone modification, without altering the DNA sequence.
Mechanisms include DNA methylation, histone modification and non-coding RNAs. Marks can be influenced by diet, stress and toxins, and some are inherited through cell division. The Dutch Hunger Winter study linked prenatal famine to later health outcomes.
Epigenetic changes are reversible, unlike mutations.
Heritable changes in gene activity, through DNA methylation and histone modification, without altering the DNA sequence.
Epigenetics is one of the 54 topics in Genetics. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include Genomic Imprinting, Mutations, Genetic Counselling.
Identical twins show growing epigenetic differences with age.
Work through the Beginner topics in Genetics first, such as Heredity, Gene, Allele, then return to Epigenetics. Advanced topics assume the Intermediate vocabulary.
The closest topics to Epigenetics are Genomic Imprinting, Mutations, Genetic Counselling, Heritability. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Epigenetics. To practise the whole of Genetics, use the Genetics quiz.
Epigenetics: Heritable changes in gene activity, through DNA methylation and histone modification, without altering the DNA sequence. Genomic Imprinting: Parent-of-origin-specific gene expression caused by epigenetic marks, as seen in IGF2 and H19. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Genomic Imprinting and explain the difference aloud. Finally, take the Genetics quiz and come back to this page for any question you miss.
Parent-of-origin-specific gene expression caused by epigenetic marks, as seen in IGF2 and H19.
🧬 GeneticsPermanent changes in the DNA sequence that can be harmless, harmful or occasionally beneficial.
🧬 GeneticsProfessional guidance that helps families understand inherited disease risk and testing options.
🧬 GeneticsThe proportion of phenotypic variation in a population attributable to genetic differences.
🧬 Genetics