RNAs longer than 200 nucleotides that regulate chromatin and gene expression, such as XIST.
lncRNAs can act as scaffolds, guides or decoys. XIST coats one X chromosome for inactivation, HOTAIR guides repressive complexes. Many are poorly conserved and their functions are still being studied.
RNAs longer than 200 nucleotides that regulate chromatin and gene expression, such as XIST.
Long Non-Coding RNA is one of the 52 topics in Molecular Biology. It is rated Advanced, so it suits learners who want specialist depth. Related topics in this area include microRNA, Chromatin Remodelling, DNA Methylation.
XIST expression is the trigger of X inactivation in females.
Work through the Beginner topics in Molecular Biology first, such as Central Dogma, DNA Replication, Base Pairing, then return to Long Non-Coding RNA. Advanced topics assume the Intermediate vocabulary.
The closest topics to Long Non-Coding RNA are microRNA, Chromatin Remodelling, DNA Methylation, Riboswitches. Comparing them side by side is a good way to see how the ideas connect.
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Long Non-Coding RNA. To practise the whole of Molecular Biology, use the Molecular Biology quiz.
Long Non-Coding RNA: RNAs longer than 200 nucleotides that regulate chromatin and gene expression, such as XIST. microRNA: About 22-nucleotide RNAs that fine-tune gene expression by blocking translation or promoting mRNA decay. Read both side by side and note what each one explains.
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with microRNA and explain the difference aloud. Finally, take the Molecular Biology quiz and come back to this page for any question you miss.
About 22-nucleotide RNAs that fine-tune gene expression by blocking translation or promoting mRNA decay.
🧫 Molecular BiologyATP-dependent complexes slide or evict nucleosomes to control access to DNA.
🧫 Molecular BiologyAddition of methyl groups to cytosine, usually silencing gene expression.
🧫 Molecular BiologyRNA elements that bind small metabolites and change structure to regulate gene expression directly.
🧫 Molecular Biology