Summary
An action potential triggers calcium entry, vesicle release of transmitter and receptor binding on the postsynaptic cell.
In depth
Action potential opens voltage-gated Ca2+ channels; Ca2+ triggers vesicle fusion via SNAREs; neurotransmitter diffuses and binds ionotropic (fast) or metabotropic (slow) receptors; it is cleared by reuptake or enzymatic breakdown.
Synaptic delay is about 0.5 ms. Calcium is needed for release. Receptor desensitisation limits responses. Drugs affect each step.
Example: botulinum toxin blocks acetylcholine release.
Frequently asked questions
What is Synaptic Transmission?
An action potential triggers calcium entry, vesicle release of transmitter and receptor binding on the postsynaptic cell.
Which area of biology covers Synaptic Transmission, and how advanced is it?
Synaptic Transmission is one of the 54 topics in Neuroscience. It is rated Intermediate, so it suits learners who already know the core vocabulary. Related topics in this area include Neuropharmacology, Neurotransmitters, Depolarisation and Repolarisation.
Can you give an example of Synaptic Transmission?
SSRIs block serotonin reuptake.
What should I learn before Synaptic Transmission?
Work through the Beginner topics in Neuroscience first, such as Nervous System, Neuron, Central and Peripheral Nervous Systems, then return to Synaptic Transmission. Intermediate topics assume the Beginner vocabulary.
What topics are related to Synaptic Transmission?
The closest topics to Synaptic Transmission are Neuropharmacology, Neurotransmitters, Depolarisation and Repolarisation, Action Potential. Comparing them side by side is a good way to see how the ideas connect.
How can I check that I understand Synaptic Transmission?
Read the summary and the in-depth section, then use the quick check on the interactive lesson for Synaptic Transmission. To practise the whole of Neuroscience, use the Neuroscience quiz.
How is Synaptic Transmission different from Neuropharmacology?
Synaptic Transmission: An action potential triggers calcium entry, vesicle release of transmitter and receptor binding on the postsynaptic cell. Neuropharmacology: Drugs act on receptors, transporters or enzymes to alter synaptic transmission. Read both side by side and note what each one explains.
How should I study Synaptic Transmission step by step?
First, read the summary and write the definition in your own words. Second, read the in-depth section and note any example. Third, compare it with Neuropharmacology and explain the difference aloud. Finally, take the Neuroscience quiz and come back to this page for any question you miss.